Fig. 3.

Suggested treatment algorithm for CRPS. Derived from Bharwani et al. [7]. ¹New IASP clinical diagnostic criteria for CRPS [8]. ²The sIL-2R is a surrogate marker for T-cell activation [30]. Although serum sIL-2R may not be useful in establishing the diagnosis of CRPS [209], we use the biomarker for monitoring the activity of (T-cell mediated) inflammation in CRPS. ³Predominant CRPS mechanisms at history taking and physical examination. CRPS complex regional pain syndrome, IASP International Association for the Study of Pain, sIL-2R soluble interleukin-2 receptor