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. 2022 Jan 24;148(5):1045–1055. doi: 10.1007/s00432-021-03854-6

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Fig. 2 — Proliferation in the conical agarose microwell array. A Sketch depicting the experimental approach. Proliferation of RPMI-8226 was assessed in a flat two-dimensional (2D) monolayer as compared to liquid overlay technique (LOT) versus the 3D conical agarose microwell array (3D CoSeedis^™) platform. B ATP content indicates a bell-shaped growth pattern for RPMI-8226 cells in the 2D and LOT model. Cell growth in the 3D microwell model was delayed but followed a sigmoidal pattern and was ongoing after 12 days of observation