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. 2022 Mar 7;59(5):3016–3039. doi: 10.1007/s12035-022-02764-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Gene expression in the cerebral cortex of 3 month-old mice of the indicated genotypes. qPCR analysis of genes preventing processing, accumulation and toxicity of Aβ (a); genes not detected by RNA-seq that are involved in Aβ aggregation and processing (b); genes involved in the PACAP signaling pathway (c), Thbs4, which regulates neurite outgrowth and synapse formation (d); Irs2, which regulates insulin signaling (e); genes involved in oxidative stress regulation (f); genes involved in vascular integrity (g); and brain welfare markers (h). Relative gene expression was normalized to Rps18 rRNA levels and expressed as 2ΔCt (obtained values were adjusted by the factor indicated between brackets). WT/EGFP (5 females), WT/E2F4DN (3 males and 3 females), 5xFAD/EGFP (5 females), and 5xFAD/E2F4DN (4 females). *p < 0.05; **p < 0.01; ***p < 0.001 (Unbalanced two-way ANOVA, followed by post hoc Student’s t test)