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. 2022 Apr 18;8:208. doi: 10.1038/s41420-022-01018-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Heat map showing distinct level of mRNAs in control and siGBP2 cells. In the clustering analysis, red indicates upregulated genes, green indicates downregulated genes, and gray dots represent genes showing no change in expression. B The pathway enrichment analysis using IPA analysis with GBP2 knockdown according to microarray datasets. C IPA analysis of biological protein interactions with GBP2 involved in EGFR signaling pathway according to microarray datasets. D Western blotting results showing changes in protein levels in the EGFR signaling pathway. U87 cells with GBP2 overexpression or depletion are analyzed.