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. 2022 Apr 18;13(4):360. doi: 10.1038/s41419-022-04845-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Circos plot displayed the genes with a high frequency of CNV change on human chromosomes. The red arrow denotes MEOX2. B Different types of MEOX2 genetic alterations in glioma samples from TCGA database (n = 656). C The correlation of MEOX2 expression with its CNV. D The mRNA levels of MEOX2 in gliomas with different WHO grades from TCGA and CGGA databases. E Overall survival (OS) curves of patients with glioma from TCGA and CGGA databases stratified by MEOX2 expression. F The protein expression of MEOX2 in gliomas with different histological grades was detected by immunoblot. G The protein expression of MEOX2 in different glioma cell lines or glioma stem cells and NHA were evaluated by immunoblot. H Representative IHC images of MEOX2 protein in gliomas with different histological grades and NBT. Bar = 20 µm. I The semi‑quantitative for the IHC results of MEOX2. **p < 0.01, ****p < 0.0001.