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. 2022 Apr 18;13(4):362. doi: 10.1038/s41419-022-04836-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Generation of OPTN (E50K) mutant homozygote of mice based on CRISPR/Cas9-mediated genome editing. B Based on PCR product sequencing, homozygous mutant mice were identified and used as E50K mice in this study. C The IOP in mice eyes based on measurement of a rebound tonometer (P > 0.05, n = 16–18). D, E The anterior chamber structures of mice were imaged through AS-OCT, and three parameters, ACD (the distance from the posterior cornea surface to the anterior surface of the lens), AOD (the distance between the posterior cornea and anterior iris surface, along a line perpendicular to the cornea at 500 μm from the point of iridoscleral contact), and ACW (the distance between the two iridoscleral contacts) were analyzed. Scale bar in D, 250 μm. (P > 0.05, n = 8–16).