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. 2022 Apr 18;13(4):362. doi: 10.1038/s41419-022-04836-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B F-VEP was used to access the light reflex in WT and E50K mice. (WT-3M, 21.2 ± 1.6, n = 31, E50K-3M, 21.6 ± 1.9, n = 21, WT-16M, 17.1 ± 0.7, n = 41, E50K-16M, 12.4 ± 0.7, n = 43). C With a designed Light/Dark Transition apparatus, the length of time the free-roaming mice spent in light space was monitored. (WT-3M, 188.8 ± 9.9, n = 17, E50K-3M, 183.6 ± 18.3, n = 10, WT-16M, 175.2 ± 18.3, n = 22,E50K-16M, 234.4 ± 12.9, n = 31). D–F With a designed OMR test apparatus, the head movement was captured to indicate the response to object movement at different frequencies in the environment. The top-view photograph of the OMR system consisted of a visual stimulus unit, which displays clockwise rotation of black-and-white stripes on 4 LCD screens (D, E). The number of OMR under each condition was analyzed (F). ①0.05 cpd: WT-3M, 10.5 ± 0.5, n = 36, E50K-3M, 12.1 ± 0.9, n = 11, WT-16M, 11.4 ± 0.62, n = 13, E50K-16M, 3.6 ± 0.4, n = 16. ②0.1 cpd: WT-3M, 9.4 ± 0.5, n = 36, E50K-3M, 8.9 ± 0.8, n = 13, WT-16M, 8.8 ± 0.8, n = 19, E50K-16M, 4.5 ± 0.4, n = 16. ③0.2 cpd: WT-3M, 9.3 ± 0.7, n = 24, E50K-3M, 8.2 ± 0.8, n = 10, WT-16M, 8.2 ± 0.8, n = 17, E50K-16M, 3.8 ± 0.3, n = 14. (*P < 0.05, **P < 0.01, ***P < 0.001).