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. 2022 Apr 18;13(4):362. doi: 10.1038/s41419-022-04836-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B The retinal thickness was measured by PS-OCT. Scale bar in A, 500 μm (left panel), 100 μm (right panel). (E50K-16M, 179.7 ± 3.4, n = 9, WT-16M, 193.8 ± 1.7, n = 9, P < 0.01). C, D The paraffin section of retinal tissue was stained by H&E. According to the previous data, we found the inhomogeneity of retinal thickness. Therefore, four parts of NC (nasal center), NP (nasal periphery), TC (temporal center) and TP (temporal periphery) were grouped to measure the total thickness of retinal-associated layers (RNFL, GCL and IPL) in each retina sample. Scale bars in C, 200 μm (upper panel), 50 μm (lower panel). (NC: WT-16M, 60.7 ± 0.7, n = 10, E50K-16M, 54.3 ± 1.6, n = 9; NP: WT-16M, 45.7 ± 2.1, n = 10, E50K-16M, 38.7 ± 1.2, n = 10; TC: WT-16M, 67.4 ± 1.5, n = 9, E50K-16M, 60.7 ± 1.1, n = 10; TP: WT-16M, 42.9 ± 0.9, n = 10, E50K-16M, 35.1 ± 1.2, n = 10). (**P < 0.01, ***P < 0.001).