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CRISPR gene editing in T-cells. Several gene KO and KI have been tested in T-cells, here we summarized the targeted genes. T cell checkpoint inhibitory receptor KO such as TIM3, CTLA-4 and PD-1 KO resulted in higher antitumor activity of T-cells. CAR-T cell signaling modulation via inhibition of immunosuppressive TGF-β signaling showed significant improvement of CAR-T cells. Integration of CAR-T in TRAC locus may solve the mentioned problems with allogeneic CAR-T therapies.
