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CRISPR gene editing in NK cells. Several gene KO in NK cells have been done to improve NK cell function; here, we show some of the NK cell gene modifications. CD38 and SOCS/CISH KO can improve metabolism in NK cells. Inhibitory checkpoint receptor KO such as NKG2A and PD-1 KO. ADAM17 KO enhance CD16 mediated ADCC. Anti-CD19 CAR NK cells increase IL-15 production and enhance NK cell anti-tumor activity.
