Skip to main content
. 2022 Apr 5;13:869050. doi: 10.3389/fimmu.2022.869050

Figure 6.

Figure 6

The protective effects of liraglutide on hepatic IRI are partly diminished in GLP-1R- knockout mice. A mouse liver partial IRI model was established using C57BL/6J mice and GLP-1R-/- mice. (A)qRT-PCT was performed to detect GLP-1R expression in KCs from sham-operated, Lira-treated, I/R, and I/R+ Lira-treated groups (n = 3 per group). Serum levels of ALT (B) and AST (C) in each group (n = 4–6 per group). (D) Liver injury, neutrophil infiltration, hepatocyte apoptosis, and macrophage phenotyping were assessed via H&E staining, MPO, TUNEL assays, and immunofluorescence staining, respectively. Quantitation of liver injury (E), neutrophil infiltration (F), hepatocyte apoptosis (G), and macrophage phenotyping (H) in each group (n = 3 per group). These results were obtained from at least three independent experiments. All values are expressed as mean ± SD. **P < 0.01, ***P < 0.001 vs. the Sham group; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. the I/R group. &P < 0.05, &&P < 0.01 vs. the I/R+Lira group.