Figure 6.

(A) In vivo release profiles of (i) VEGF and (ii) BMP-2 were obtained after implantation of scaffold into the subcutaneous tissue mice for 28 days,³⁰³ where CSB and CSV represent nanocomposite fibrous scaffold (CS) loaded with BMP2 (B) and VEGF (V), respectively [Reproduced with permission from ref 303. Copyright 2018 Elsevier]. (B) Release kinetics of PLGA microspheres steady release of neurotrophic growth factors was detected for at least 60 days (i, BDNF) and 80 days (ii, GDNF) [Reproduced with the permission from ref 358. Copyright 2010 Springer Nature]. (C) Normalized in vivo release profile of BMP-2 from the four different implants in a rat subcutaneous implantation model, where Mps = PLGA microparticles loaded with BMP-2, and PPF = poly(propylene fumarate) [Reproduced with the permission from ref 359. Copyright 2008 Elsevier]. (D) Cumulative release of VEGF from the biohybrid scaffold with PLGA nanofibers, which displays a sustained release of VEGF over 28 days [Reproduced with the permission from ref 355. Copyright 2014 Elsevier].