Table 2.

Summary of CHLA15‐Ctrl (DX) and CHLA15‐shMFN2 and ‐shPACS2 models.

	CHLA15‐ctrl	CHLA15‐shMFN2		CHLA15‐shPACS2
Mitochondria
Number analyzed	214	234		246
Perimeter, mean (nm)	1,416	1,468	P = ns	1,530	P < 0.01
Perimeter, median (nm)	1,319	1,381		1,453
Circularity, median	0.918	0.892	P = 0.03	0.914	P = ns
Roundness, median	0.715	0.655	P < 0.01	0.686	P = ns
% with 0 MAMs	19%	33%	P < 0.01	24%	P = ns
% with 1 MAMs	37%	39%		39%
% with 2–3 MAMs	37%	26%	P < 0.01	22%	P = ns
% with ≥ 4 MAMs	6%	1%		5%
%OMM with MAM gap width ≤ 10 nm	1.7%	0.9%	(↓47%)	1.0%	(↓41%)
%OMM with MAM gap width ≤ 25 nm	5.9%	3.0%	(↓49%)	3.5%	(↓41%)
%OMM with MAM gap width ≤ 50 nm	12.6%	7.8%	(↓38%)	9.3%	(↓26%)
%OMM with MAM gap width ≤ 10 nm	27.4%	17.8%	(↓35%)	21.2%	(↓23%)
MAM
Number analyzed	330	241		331
MAMs per mitochondria	1.54	1.03	P < 0.01	1.35	P = 0.07
MAM frequency (per nm perimeter)	918	1,425		1,137
%MAM with gap width ≤ 10 nm	22%	17%	P = 0.09	15%	P = 0.02
%MAM with gap width ≤ 25 nm	47%	43%	P = ns	40%	P < 0.05
%MAM with gap width ≤ 50 nm	68%	73%	P = ns	71%	P = ns
%MAM with gap width ≤ 100 nm	100%	100%		100%