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. 2022 Mar 14;41(8):e109365. doi: 10.15252/embj.2021109365

Figure 6. Aberrant activation of YAP/TAZ‐mTORC1 signaling in the human lungs of bronchiolitis obliterans syndrome (BO).

Figure 6

  1. Representative H&E images of human lung tissues from normal background and bronchiolitis obliterans (BO) with progressive fibrosis.
  2. Representative IF images showing the expressions of nuclear YAP, DATP marker CLDN4, and AT1 cell marker AQP5 in the airways of normal background (top) and BO (bottom) human lungs. CLDN4 (white), AQP5 (red), YAP (green), and DAPI (blue). Of note, a flattened airway layer in BO lungs. Scale bars, 100 μm.
  3. Representative IF images showing the expressions of secretory cell marker CC10 and mTORC1 activation marker p‐S6 in the airways of normal background (top) and BO (bottom) human lungs. CC10 (green), p‐S6 (white), and DAPI (blue). Scale bars, 100 μm.
  4. Representative IF images showing the expression of nuclear YAP, ATF4, and AQP5 in the airways of normal background (top) and BO (bottom) human lungs. YAP (green), ATF4 (white), AQP5 (red), and DAPI (blue). Of note, co‐expressions of nuclear YAP, nuclear ATF4, and AQP5 in the airways of BO lungs. Scale bars, 100 μm.
  5. Representative IF images showing the expression of p‐S6 (white) in the airway cells losing CC10 (green) expression of BO human lungs. Scale bars, 100 μm.