Table 2.
Study Characteristics, Incident Rates, and Hazard Ratios for Each Outcome
| Outcomes | Number of Individualsa N | Number of Events N (%)b | Incident Rates IR per 1000 Person-Years | Person Years Total Person Years | Crude HR Crude HR (95% CI) | Adjusted HRc Adjusted HR (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| People With HIV | People Without HIV | People With HIV | People Without HIV | People With HIV | People Without HIV | People With HIV | People Without HIV | People With HIV vs People Without HIV | People With HIV vs People Without HIV | |
| Composite CVDd | 8880 | 35 877 | 207 (2.3) | 683 (1.9) | 5.33 | 3.69 | 38 814.8 | 184 877.8 | 1.49 (1.27–1.74)** | 1.50 (1.28–1.77)** |
| Peripheral vascular disease | 9185 | 36 673 | 39 (0.4) | 137 (0.4) | 0.96 | 0.72 | 40 719.3 | 191 012.5 | 1.37 (0.96–1.95) | 1.32 (0.91–1.91) |
| Stroke | 9081 | 36 505 | 72 (0.8) | 238 (0.7) | 1.79 | 1.25 | 40 205.1 | 189 856.1 | 1.47 (1.13–1.92)** | 1.42 (1.08–1.86)* |
| Myocardial infarction | 9131 | 36 573 | 51 (0.6) | 191 (0.5) | 1.26 | 1.00 | 40 440.0 | 190 268.5 | 1.29 (0.95–1.76) | 1.30 (0.94–1.79) |
| Ischemic heart disease | 9059 | 36 275 | 108 (1.2) | 345 (1.0) | 2.71 | 1.84 | 39 911.4 | 187 995.5 | 1.52 (1.22–1.89)** | 1.55 (1.24–1.94)** |
| Heart failure | 9184 | 36 717 | 42 (0.5) | 148 (0.4) | 1.03 | 0.77 | 40 750.5 | 191 305.1 | 1.36 (0.96–1.91) | 1.32 (0.92–1.89) |
| Hypertension | 8520 | 33 616 | 456 (5.4) | 1666 (5.0) | 12.70 | 9.93 | 35 911.6 | 167 722.7 | 1.30 (1.17–1.44)** | 1.37 (1.23–1.53)** |
| Type 2 diabetes | 8926 | 35 559 | 197 (2.2) | 862 (2.4) | 5.06 | 4.72 | 38 940.8 | 182 682.4 | 1.09 (0.93–1.27) | 1.28 (1.09–1.50)** |
| Chronic kidney disease | 9135 | 36 558 | 160 (1.8) | 337 (0.9) | 3.99 | 1.78 | 40 065.2 | 189 728.9 | 2.32 (1.92–2.80)** | 2.42 (1.98–2.94)** |
| All-cause mortality | 9233 | 36 816 | 384 (4.2) | 559 (1.5) | 9.35 | 2.91 | 41 059.2 | 192 215.8 | 3.25 (2.85–3.70)** | 2.84 (2.48–3.25)** |
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; HIV, human immunodeficiency virus; HR, hazard ratio; IR, incident rate.
aThe number of participants will differ for each outcome. This is due to the exclusion of participants that already had the outcome at baseline.
bPercentages correspond with the number of events (numerator) and the number of individuals for that particular group (denominator) within the corresponding row.
cAdjusted for age, body mass index, sex, smoking status, ethnicity, deprivation, index year, and events at baseline.
dComposite CVD comprises peripheral vascular disease, stroke, myocardial infarction, ischemic heart disease, and heart failure events.
*P < .05.
**P < .01.