Table 3.
Subgroup Analysisa for Composite and Individual CVDs; Adjusted Hazard Ratios for People With HIV Compared With People Without HIV, With 95% CIs Presented
| Sub-groups | Composite CVDb | Peripheral Vascular Disease | Stroke | Myocardial Infarction | Ischemic Heart Disease | Heart Failure |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 1.47 (1.22–1.76)** | 1.36 (0.91–2.03) | 1.43 (1.04–1.97)* | 1.19 (0.84–1.70) | 1.47 (1.15–1.89)** | 1.19 (0.78–1.81) |
| Female | 1.60 (1.12–2.29)* | 1.02 (0.36–2.90) | 1.49 (0.85–2.61) | 2.15 (0.96–4.80) | 1.82 (1.04–3.20)* | 1.80 (0.89–3.67) |
| Age | ||||||
| <40 years old | 1.50 (1.01–2.24)* | 0.37 (0.05–2.87) | 1.40 (0.73–2.71) | 1.64 (0.76–3.54) | 2.08 (1.15–3.77)* | 2.42 (1.12–5.22)* |
| ≥40 years old | 1.50 (1.26–1.79)** | 1.41 (0.96–2.06) | 1.41 (1.04–1.91)* | 1.23 (0.86–1.75) | 1.47 (1.15–1.88)** | 1.12 (0.74–1.69) |
| Ethnicity | ||||||
| Non-Whitec | 1.34 (0.89–2.02) | 1.07 (0.18–6.21) | 1.87 (1.05–3.36)* | 0.76 (0.25–2.27) | 1.25 (0.65–2.41) | 1.12 (0.51–2.44) |
| White | 1.52 (1.20–1.94)** | 1.34 (0.77–2.32) | 1.23 (0.81–1.87) | 1.69 (1.07–2.67)* | 1.58 (1.13–2.23)** | 1.27 (0.73–2.22) |
| Deprivation | ||||||
| Most deprived | 1.24 (0.86–1.79) | 1.13 (0.50–2.55) | 1.38 (0.77–2.46) | 1.43 (0.67–3.02) | 1.44 (0.84–2.45) | 0.88 (0.42–1.85) |
| Least deprived | 1.25 (0.74–2.10) | 0.87 (0.24–3.17) | 1.40 (0.58–3.38) | 1.67 (0.68–4.10) | 1.28 (0.62–2.64) | 0.52 (0.07–4.12) |
| Body Mass Index | ||||||
| Obese | 1.30 (0.88–1.92) | 1.28 (0.55–3.01) | 1.65 (0.88–3.09) | 0.77 (0.31–1.96) | 1.35 (0.79–2.31) | 0.76 (0.34–1.68) |
| Not Obese | 1.53 (1.25–1.88)** | 1.34 (0.84–2.15) | 1.36 (0.95–1.95) | 1.38 (0.94–2.03) | 1.62 (1.24–2.13)** | 1.32 (0.81–2.15) |
| Smoker Status | ||||||
| Current or ex-smoker | 1.45 (1.16–1.80)** | 1.11 (0.71–1.75) | 1.36 (0.92–2.00) | 1.27 (0.85–1.90) | 1.45 (1.08–1.96)* | 1.49 (0.92–2.41) |
| Never smoked | 1.43 (1.09–1.88)* | 1.74 (0.80–3.81) | 1.38 (0.89–2.13) | 1.39 (0.76–2.54) | 1.63 (1.11–2.40)* | 1.27 (0.72–2.26) |
| Index Year | ||||||
| 2000–2009 | 1.51 (1.24–1.86)** | 1.51 (0.96–2.38) | 1.35 (0.96–1.91) | 1.28 (0.85–1.92) | 1.68 (1.28–2.21)** | 1.21 (0.75–1.96) |
| 2010–2019 | 1.49 (1.14–1.95)** | 0.96 (0.50–1.87) | 1.58 (1.00–2.50) | 1.32 (0.76–2.24) | 1.32 (0.88–1.97) | 1.41 (0.82–2.42) |
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; HIV, human immunodeficiency virus.
aAdjusted for age, body mass index, sex, smoking status, ethnicity, deprivation, index year, and events at baseline.
bComposite CVD comprises peripheral vascular disease, stroke, myocardial infarction, ischemic heart disease, and heart failure events.
cNon-White subgroup includes people that identify as Black, Asian, mixed, or other.
*P < .05.
**P < .01.