At risk |
Patients treated with bone-modifying agents but without apparent necrotic bone (eg, all asymptomatic patients treated with antiresorptives) |
Stage 0 |
No clinical evidence of necrotic bone but nonspecific symptoms or clinical/radiographic findings |
Stage 1 |
Exposed and necrotic bone, or fistulae that probe to bone, that are asymptomatic with no evidence of significant adjacent or regional soft-tissue inflammation or infection |
Stage 2 |
Exposed and necrotic bone, or fistulae that probe to bone, associated with infection, evident by pain and adjacent or regional soft-tissue inflammatory swelling, with or without purulent drainage |
Stage 3 |
Exposed and necrotic bone, or fistulae that probe to bone, associated with pain and infection, and at least one of the following: (1) pathologic fracture, (2) extra-oral fistula, (3) oral-antral fistula, or (4) radiographic evidence of osteolysis extending to the inferior border of the mandible or floor of the maxillary sinus |
Nonexposed variant (not widely adopted) |
Presence of otherwise unexplained pain in the jaws, fistula, swelling, mobile teeth, or mandibular fracture diagnosed after excluding common diseases of the jaw known to cause similar manifestations |