Table 1.
Cox Proportional Hazard Model to Determine Impact of Long-Lasting Insecticidal Net/Insecticidal Exposure on Survival of Field-Caught Anopheles gambiae Sensu Lato 72 Hours After Exposurea
Insecticide Exposure | No. (No. of Events) | HRR (95% CI) | P Valueb |
---|---|---|---|
Untreated netting | Reference | ||
PermaNet 2.0 (deltamethrin only) | 1135 (1047) | 1.095 (.968–1.239) | .15 |
PermaNet 3.0 side panels (deltamethrin only) | 1157 (1088) | 0.9664 (.9092–1.027) | .27 |
PermaNet 3.0 roof panels (PBO + deltamethrin) | 563 (533) | 1.007 (.939–1.079) | .85 |
Acetone control | Reference | ||
Alpha-cypermethrin 1× | 676 (641) | 1.006 (.9696–1.043) | .77 |
Deltamethrin 1× | 683 (645) | 0.9942 (.9539–1.036) | .78 |
Permethrin 1× | 693 (661) | 1.015 (.9698–1.062) | .52 |
Clothianidin 1× | 698 (581) | 1.208 (.9227–1.581) | .17 |
Chlorfenapyr 1× | 708 (580) | 1.692 (1.086–2.637) | .02 |
PBO + deltamethrin 1× | 630 (577) | 0.9662 (.2411–3.873) | .96 |
Alpha-cypermethrin 5× | 633 (601) | 0.9951 (.9407–1.053) | .86 |
Deltamethrin 5× | 652 (610) | 0.9942 (.9393–1.052) | .84 |
Permethrin 5× | 636 (583) | 0.9931 (.8638–1.142) | .92 |
Alpha-cypermethrin 10× | 624 (587) | 0.9951 (.917–1.08) | .91 |
Deltamethrin 10× | 623 (588) | 0.9943 (.9072–1.09) | .90 |
Permethrin 10× | 656 (603) | 1.026 (.9509–1.107) | .51 |
1× Insecticide dose | Reference | ||
Alpha-cypermethrin 5× | 117 (92) | 1.016 (.9069–1.138) | .78 |
Alpha-cypermethrin 10× | 108 (78) | 1.007 (.9403–1.078) | .84 |
Deltamethrin 5× | 143 (105) | 1.0 (.9035–1.107) | >.99 |
Deltamethrin 10× | 114 (83) | 1.0 (.9363–1.068) | >.99 |
Permethrin 5× | 137 (94) | 1.022 (.8528–1.225) | .81 |
Permethrin 10× | 157 (114) | 0.9952 (.9491–1.044) | .84 |
Abbreviations: CI, confidence interval; HRR, hazard rate ratio (ratio of hazard rate for control/reference group to hazard rate for treatment group; PBO, piperonyl butoxide.
aImmediate mortality rates after long-lasting insecticidal net (60 minutes and 24 hours) or insecticidal exposure (30 or 60 minutes, depending on insecticide) were excluded.
bSignificance cutoff level defined as α = .05.