Table 2.
Characteristics | Women | P | Men | P | ||
---|---|---|---|---|---|---|
Risk allele carriers | Nonrisk homozygotes | Risk allele carriers | Nonrisk homozygotes | |||
No. | 27 | 32 | 24 | 16 | .22 | |
Age, y | 43.48 ± 2.21 | 43.97 ± 1.87 | .87 | 42.54 ± 2.30 | 45.33 ± 2.42 | .42 |
Disease state | ||||||
Hypertensive (n) | 18 | 24 | .57 | 15 | 11 | .75 |
Normotensive (n) | 9 | 8 | 9 | 5 | ||
BMI | 29.26 ± 1.00 | 27.92 ± 0.92 | .33 | 29.20 ± 0.86 | 28.20 ± 0.90 | .42 |
SBP on LIB diet, mm Hg | 140 ± 5 | 143 ± 4 | .63 | 137 ± 4 | 138 ± 5 | .44 |
DBP on LIB diet, mm Hg | 83 ± 3 | 83 ± 2 | .90 | 81 ± 2 | 81 ± 11 | .94 |
Aldosterone on LIB diet, ng/dL | 3.70 ± 0.42 | 4.82 ± 0.62 | .04 | 3.56 ± 0.29 | 5.63 ± 1.25 | .20 |
PRA on LIB diet, ng/mL/h | 0.29 ± 0.06 | 0.35 ± 0.07 | .69 | 0.31 ± 0.07 | 0.24 ± 0.05 | .96 |
ARR on LIB diet, ng/dL per ng/mL/h | 38.43 ± 11.59 | 30.50 ± 6.36 | .64 | 21.98 ± 3.81 | 42.15 ± 17.17 | .21 |
24-h urine sodium excretion on LIB diet, mmol/24 h | 215.29 ± 18.20 | 206.25 ± 15.32 | .70 | 245.78 ± 12.01 | 208.63 ± 21.93 | .90 |
24-h urine sodium excretion on RES diet, mmol/24 h | 19.06 ± 3.83 | 15.88 ± 1.97 | .91 | 20.93 ± 3.11 | 18.26 ± 2.61 | .99 |
Data represent mean ± SEM. T test, Wilcoxon rank sum test, or Fisher exact test was used in the analysis.
Abbreviations: ARR, aldosterone-to-renin ratio; BMI, body mass index; DBP, diastolic blood pressure; LIB, liberal salt; PRA, plasma renin activity; RES, restricted salt; SBP, systolic blood pressure.