Table 3.

The sex-LSD1 genotype interaction for aldosterone level response to angiotensin II infusion on a liberal salt diet in those of African descent

Populations	Sex	β-coefficient	95% CI	Risk allele carriers, ng/dL	Nonrisk homozygotes, ng/dL	P interaction
A whole cohort of African descent (n = 61)	Female	–3.70	–6.85 to –0.56	4.81 ± 1.09	8.51 ± 1.02	.023
	Male	2.10	–1.78 to 5.99	5.85 ± 1.01	3.75 ± 1.45
Age > 50 y (n = 19)	Female	0.52	–4.17 to 5.22	5.11 ± 1.19	4.59 ± 1.05	.63
	Male	–2.84	–17.62 to 11.93	5.23 ± 2.74	8.08 ± 3.63
Age ≤ 50 y (n = 42)	Female	–5.9	–10.34 to –1.47	4.64 ± 1.43	10.36 ± 1.34	.007
	Male	2.35	–1.68 to 6.38	5.21 ± 1.00	2.86 ± 1.51

Data represent least square mean ± SEM. Multiple regression analysis for aldosterone level response to angiotensin II infusion was adjusted for age, body mass index, sites, and disease status.

Abbreviation: LSD1, lysine-specific demethylase 1.