Table 2. Reports of Adverse Events According to Sex and Age Group.
| Variable | Respondents, No. (%) | |||||
|---|---|---|---|---|---|---|
| Total | Sex | Age, y | ||||
| Female | Male | 60-69 | 70-79 | ≥80 | ||
| Any adverse event | 8120 (30.0) | 4778 (39.0) | 3342 (22.6) | 3915 (33.2) | 3005 (25.0) | 1200 (37.0) |
| Local reaction | 6713 (24.8) | 4082 (33.3) | 2631 (17.8) | 3283 (27.9) | 2421 (20.1) | 1009 (31.1) |
| Pain at injection site | 6346 (23.5) | 3853 (31.4) | 2493 (16.9) | 3109 (26.4) | 2288 (19.0) | 949 (29.2) |
| Swelling at injection site | 1399 (5.2) | 1051 (8.6) | 348 (2.4) | 688 (5.8) | 503 (4.2) | 208 (6.4) |
| Axillary swelling in the injected arm | 356 (1.3) | 297 (2.4) | 59 (0.4) | 228 (1.9) | 100 (0.8) | 28 (0.9) |
| Other local reaction | 1116 (4.1) | 773 (6.3) | 343 (2.3) | 560 (4.8) | 437 (3.6) | 119 (3.7) |
| Systemic reaction | 4495 (16.6) | 2811 (22.9) | 1684 (11.4) | 2418 (20.5) | 1635 (13.6) | 442 (13.6) |
| Fatigue | 2634 (9.7) | 1727 (14.1) | 907 (6.1) | 1419 (12.0) | 924 (7.7) | 291 (9.0) |
| Malaise | 1950 (7.2) | 1316 (10.7) | 634 (4.3) | 1114 (9.5) | 660 (5.5) | 176 (5.4) |
| Muscle ache | 1506 (5.6) | 1041 (8.5) | 465 (3.1) | 901 (7.6) | 500 (4.2) | 105 (3.2) |
| Headache | 1326 (4.9) | 908 (7.4) | 418 (2.8) | 771 (6.5) | 445 (3.7) | 110 (3.4) |
| Low-grade fever (<38°C) | 864 (3.2) | 553 (4.5) | 311 (2.1) | 481 (4.1) | 325 (2.7) | 58 (1.8) |
| Joint aches | 670 (2.5) | 471 (3.8) | 199 (1.3) | 399 (3.4) | 202 (1.7) | 69 (2.1) |
| Nausea | 416 (1.5) | 325 (2.7) | 91 (0.6) | 253 (2.1) | 115 (1.0) | 48 (1.5) |
| Temperature >38°C | 423 (1.6) | 290 (2.4) | 133 (0.9) | 258 (2.2) | 135 (1.1) | 30 (0.9) |
| Vomiting or diarrhea | 167 (0.6) | 123 (1.0) | 44 (0.3) | 82 (0.7) | 60 (0.5) | 25 (0.8) |
| Chest pains | 159 (0.6) | 103 (0.8) | 56 (0.4) | 92 (0.8) | 52 (0.4) | 15 (0.5) |
| Shortness of breath | 110 (0.4) | 65 (0.5) | 45 (0.3) | 56 (0.5) | 32 (0.3) | 22 (0.7) |
| Irregular pulse | 135 (0.5) | 103 (0.8) | 32 (0.2) | 79 (0.7) | 40 (0.3) | 16 (0.5) |
| Disseminated rash | 50 (0.2) | 29 (0.2) | 21 (0.1) | 28 (0.2) | 16 (0.1) | 6 (0.2) |
| Facial rash | 12 (0.0) | 11 (0.1) | 1 (0.0) | 8 (0.1) | 2 (0.0) | 2 (0.1) |
| Other systemic reactions | 464 (1.7) | 271 (2.2) | 193 (1.3) | 200 (1.7) | 178 (1.5) | 86 (2.6) |
| Medical attention for any adverse event | 314 (1.2) | 187 (1.5) | 127 (0.9) | 156 (1.3) | 104 (0.9) | 54 (1.7) |
| Symptom duration, d | ||||||
| <1 | 2350 (8.7) | 1265 (10.3) | 1085 (7.3) | 1119 (9.5) | 819 (6.8) | 412 (12.7) |
| 1-3 | 1340 (5.0) | 903 (7.4) | 437 (3.0) | 637 (5.4) | 502 (4.2) | 201 (6.2) |
| >3 | 4330 (16.0) | 2567 (20.9) | 1763 (11.9) | 2115 (18.0) | 1639 (13.6) | 576 (17.7) |
| Cannot recall | 100 (0.4) | 43 (0.4) | 57 (0.4) | 44 (0.4) | 45 (0.4) | 11 (0.3) |
| Adverse events after second dose | ||||||
| Any reaction | 6198 (22.9) | 3733 (30.5) | 2465 (16.7) | 3309 (28.1) | 2238 (18.6) | 651 (20.0) |
| No reaction | 20 384 (75.4) | 8288 (67.6) | 12 096 (81.8) | 8238 (69.9) | 9595 (79.8) | 2551 (78.6) |
| Cannot recall | 464 (1.7) | 237 (1.9) | 227 (1.5) | 232 (2.0) | 187 (1.6) | 45 (1.4) |
| Third-dose reactions vs second-dose reactions | ||||||
| Felt better | 5064 (18.7) | 2266 (18.5) | 2798 (18.9) | 2537 (21.5) | 2171 (18.1) | 356 (11.0) |
| Felt similar | 18 345 (67.8) | 7818 (63.8) | 10 527 (71.2) | 7479 (63.5) | 8412 (70.0) | 2454 (75.6) |
| Felt worse | 3008 (11.1) | 1857 (15.1) | 1151 (7.8) | 1506 (12.8) | 1167 (9.7) | 335 (10.3) |
| Cannot recall | 629 (2.3) | 317 (2.6) | 312 (2.1) | 257 (2.2) | 270 (2.2) | 102 (3.1) |