Table 1.

Role of AsA and their mode of actions in various diseases

S. No	Concentration of AsA	AsA role in disease	Mode of actions of AsA on diseases	References
1	41–66 µmol/L	Cardiac disease	Prevents the low-density lipoproteins (LDL-proteins) from oxidative changes, prevention of ischemia/reperfusion and myocardial injury ameliorated the toxicity of the heavy metals	He et al. (2007); Kukongviriyapan et al. (2014); Morelli et al. (2020)
2	200 to 400 mg/kg	Alzheimer's disease	Reduced the depletion of dopamine and serotonin metabolites in cortex and striatum	Harrison (2012)
3	150 mg/day	Prostate cancer	Inhibit the angiogenesis and increase the cytotoxicity in naïve human prostate cancer cell lines	Bai et al. (2015)
4	75 g to 125 g	Pancreatic cancer	Increased the Bax/Bcl-2 expression, ROS production, DNA fragmentation and cytotoxicity of cells	Drisko et al. (2018)
5	100 µg/ml	Cervical cancer	Increased the susceptibility of cisplatin and doxorubicin drug on HeLa cells and increase the level of apoptotic protein, catalase, superoxide dismutase and endoplasmic reticulum induced p-eIF2/eif2-a ratio	Shenoy et al. (2018b)
6	50, 100 and 200 µM	Breast cancer	Induced the autophagosome by regulation of mammalian target of rapamycin (mTOR), Beclin1 and autophagy-related genes, accumulation of p62 protein, increased endoplasmic reticulum stress via IRE-JNK-CHOP signalling pathways	Bos (2019)
7	0.5 mM, 2.5 mM, and 5 mM	Parkinson disease	Decreases the level of α-synuclein-Cu2 + and accumulation of Lewy bodies	da Costa Daniele et al. (2020)
8	100 mg/kg to 4 g/kg	Colon cancer	Increases the cytotoxic effects of CD8 T cells, check the tumour growth by immune checkpoint therapy	Magrì et al. (2020)