Table 1.

Neurological autoimmune diseases and molecular mimicry

Disease	Pathogen	Pathogen epitope	Host epitope	Host	References
MS	Epstein-Barr virus	EBNA1 (386–405) SQSSSSGSPPRRPPPGRRPF	Glial Cellular Adhesion Molecule (Glial)CAM (370–389) ATGRTHSSPPRAPSSPGRSR	Human	[54]
MS	Epstein-Barr virus	EBNA1 (431–440) PGAIEQGPAD	Anoctamin 2 (140–147) PGDIELGPLD	Human	[58]
MS – EAE	Epstein-Barr virus	FARQAVWLRE	RASGRP2 (78–87)	Human	[53]
MS	Human herpesvirus 6	U24(1–13) MDPPRTPPPSYSE	MBP (92–104) IVTPRTPPPSQGK	Human	[75]
MS – EAE	Cytomegalovirus	UL86; mcp (986–993) WLRSPFSR	MOG (39–46) WYRPPFSR	Rhesus monkey	[76]
MS – EAE	Akkermansia muciniphila	LSVGWISGQY	RASGRP2 (78–87)	Human	[53]
MS – EAE	Chlamydia pneumoniae	Cpn0483 gene YGCLLPRNPRTEDQN	MBP (68–86) YGSLPQKSQRTQDEN	Lewis rat	[77]
MS	Chlamydia pneumoniae	Cpn0442 gene KNLFPPYEPPP	MBP (84–102) KNIVTPRTPPP	Lewis rat	[77]
MS	Acinetobacter calcoaceticus	3-oxoadipate COA-transferase subunit A (83–97) DSYVFDELYRAGKIE	MOG (43–57) PFSRVVHLYRNGKDQ	Human	[78]
MS	Acinetobacter calcoaceticus	4-carboxy-muconolactone decarboxylase (38–52) QNFISRFAWGEVNSR	MBP (110–124) GLSLSRFSWGAEGQR	Human	[78]
MS	Pneumocystis aeruginosa	γ-carboxy-muconolactone decarboxylase (38–52) QEMITRHAWGDIWTR	MBP(110–124) GLSLSRFSWGAEGQR	Human	[78]
MS – EAE	Lactobacillus reuteri	UvrA peptide TIKREGFVRVQVD	MOG(38–50) GWYRSPFSRVVHL	Mouse C57Bl/6	[51]
NMOSD	Clostridium perfringens	ABC transporter permease(204–217) FIILPVSMVLISLV	AQP4 (63–76) EKPLPVDMVLISLC	Human	[79]
NMOSD	Human T-lymphotropic virus	TAX1BP1 protein (219–233) EFKKRFSDATSKAHQ	AQP4 (6–20) EFKRRFKEAFSKAAQ	Human	[80]
Narcolepsy	Influenza virus H1N1	pHA273–287 AMERNAGSGIIISDT	Hypocretin/orexin 54–66 HGAGNHAAGILTL	Human	[81, 82]

Bold letters indicate amino acids identical in both epitopes.

MS: multiple sclerosis, NMOSD: neuromyelitis optica spectrum disorder, GBS: Guillain-Barré syndrome, HCRT: hypocretin/orexin