Table 1. Sequence Description of Candidate DC-specific Transcription Factor Response Elements Identified Using a 7-Step Informatics Workflow as Described in Figure 1.
| TFRE | TFRE sequence | cognate TF(s) | gene source | gene class | start | end | strand |
|---|---|---|---|---|---|---|---|
| IRF9-A | ctaaaccgagaatcgaaactaagct | IRF9 | PML | upregulated | 1066 | 1090 | + |
| c-Rel-A | cttggggtttccaac | c-Rel | SDC4 | upregulated | 848 | 862 | + |
| SPI1-A | gtgaaggaggaagtctgaggc | SPI1 (PU.1) | TYROBP | moDC | 982 | 1002 | – |
| IRF4-A | ataggagggctaaagaaagcagaaa | IRF4 | FPR3 | moDC | 942 | 966 | – |
| JUNB-A | ctcttagtcaccg | JUNB | CCL22 | moDC | 924 | 936 | – |
| STAT5A-A | aggtttccgagtattgctt | STAT5A | FCN1 | cDC | 681 | 699 | + |
| BATF-A | tcctgactcactg | BATF, JUNB | MRC1 | moDC | 1 | 13 | + |
| IRF8-A | ctagattcgaaaccaaaccctgtga | IRF8, IRF4 | STAT2 | upregulated | 21 | 45 | – |
| RELA-A | gaaggactttccagc | RELA (p65) | NFKBIA | upregulated | 756 | 770 | + |
| IK1-A | catcgggaacacc | IKZF1 (IK1) | CORO1A | cDC | 451 | 463 | – |
| c-Rel-B | gaaggagattccttc | c-Rel | RBBP8 | upregulated | 454 | 468 | + |
| SPI1-B | aagcaaggggaagcaggcctc | SPI1 | ITGAX | cDC | 173 | 193 | – |
| IRF4-B | gtagatgtggaagtgaaagctacaa | IRF4, SPI1 (PU.1) | CD74 | mo/cDC | 891 | 915 | – |
| JUNB-B | gcctgagtcaccg | JUNB | C1orf162 | cDC | 562 | 574 | – |
| BATF-B | tcttgactcagtc | BATF, JUNB | CD1A | moDC | 718 | 730 | + |