Figure 5.

(a) Number of contacts (normalized to one) n_NS that are shared with the folded structure as measured in each of the five regions A to E of the transition pathway. The subset of long-range contacts n_LR, again normalized to one, is drawn separately. Shown are also the number n_FS of contacts also found in the fibril reference structure. In (b), we show the relative frequency with which one of the three characteristic helices of the folded structure, or the two main β-strands of the fibril structure, is observed.