Figure 5.

Remdesivir does not distort RNA structure

(A–F) Major (A) and minor (B) groove width, Watson-Crick base pairing (C), roll (D), twist (E), and RMSD (F) of the double helix are not affected when remdesivir is present (purple) with respect to control sequence (black) during MD simulations. The average values across the simulations are shown in black and purple dots for the control and remdesivir-containing sequences, respectively. Average standard deviations are shown as black and purple bars. The RMSD of one of the five replicas is shown in (F) (see also Figure S11).