Summary of findings 3. Vasopressin versus placebo to reduce blood loss during myomectomy for fibroids.
| Vasopressin versus placebo to reduce blood loss during myomectomy for fibroids | ||||||
| Patient or population: Women with fibroids Settings: Middle and low income countries Intervention: Vasopressin Comparison: Placebo | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Placebo | Vasopressin | |||||
| Blood loss (ml) Estimated blood loss during myomectomy | The mean blood loss in the placebo groups was 483.09 ml | The mean blood loss in the vasopressin groups was 245.87 ml lower (434.58 to 57.16 lower) | MD ‐245.87 (‐434.58 to ‐57.16) | 128 (3 studies) | ⊕⊕⊕⊝ moderate1 | We rated down the quality of evidence (by 1) because the data were derived from three small studies and we could not rule out the possibility of publication bias We did not rate down the evidence due to heterogeneity because this could be explained by the fact that in one study women had laparoscopic myomectomy and two other studies, women has open abdominal myomectomy |
| Need for blood transfusion Participants who received blood transfusion | 222 per 1000 | 33 per 1000 (7 to 164) | OR 0.15 (0.03 to 0.74) | 90 (2 studies) | ⊕⊕⊕⊝ moderate1 | We rated down the quality of evidence (by 1) because the data were derived from two small studies and we could not rule out the possibility of publication bias |
| Duration of surgery Operative time | The mean duration of surgery in the placebo groups was 111.45 min | The mean duration of surgery in the vasopressin groups was 27.72 min lower (35.82 to 19.61 lower) | MD ‐27.72 (‐35.82 to ‐19.61) | 108 (2 studies) | ⊕⊕⊕⊝ moderate1 | We rated down the quality of evidence (by 1) because the data were derived from two small studies and we could not rule out the possibility of publication bias |
| CI: Confidence interval; MD: mean difference; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1In all the trials, allocation concealment was unclear.