Summary of findings 4. Bupivicaine plus epinephrine compared to placebo to reduce blood loss during myomectomy for fibroids.
| Bupivicaine plus epinephrine compared to placebo to reduce blood loss during myomectomy for fibroids | ||||||
| Patient or population: Women with fibroids Settings: University hospital in Italy Intervention: Bupivicaine plus epinephrine Comparison: Placebo | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Placebo | Bupivicaine plus epinephrine | |||||
| Blood loss (ml) Estimated blood loss during myomectomy | The mean blood loss in the placebo group was 212.5 ml | The mean blood loss in the bupivicaine‐epinephrine group was 68.6 ml lower (93.69 to 43.51 lower) | MD ‐68.60 (‐93.69 to ‐43.51) | 60 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, with a high risk of attrition bias (2 patients in each arm did not receive assigned intervention because of concomitant disease) |
|
Need for blood transfusion Participants who received blood transfusion |
Outcome not reported by investigators | |||||
| Duration of surgery (min) Operative time | The mean duration of surgery in the placebo group was 109.2 min | The mean duration of surgery in the bupivicaine‐epinephrine group was 30.50 min lower (37.68 to 23.32 lower) | MD ‐30.50 (‐37.68 to ‐23.32) | 60 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, with a high risk of attrition bias (2 patients in each arm did not receive assigned intervention because of concomitant disease) |
| CI: Confidence interval; MD: mean difference | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1The allocation concealment was achieved by envelopes containing computer‐generated random numbers.