Summary of findings 6. Gelatin‐thrombin matrix compared to placebo or no treatment to reduce blood loss during myomectomy for fibroids.
| Gelatin‐thrombin matrix compared to placebo or no treatment to reduce blood loss during myomectomy for fibroids | ||||||
| Patient or population: Women with fibroids Settings: University teaching hospital in Spain Intervention: Gelatin‐thrombin matrix Comparison: Placebo or no treatment | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Placebo | Gelatin‐thrombin matrix | |||||
| Blood loss (ml) Estimated blood loss during myomectomy | The mean blood loss in placebo groups was 625 ml | The mean blood loss in intervention groups was 545 ml lower (593.26 to 496.74 lower) | MD ‐545.00 (‐593.26 to ‐496.74) | 50 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, and it is unclear if outcome assessors were blind |
| Need for blood transfusion Participants who received blood transfusion | 400 per 1000 | 4 per 1000 (0 to 40) | OR 0.01 (0 to 0.1) | 50 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, it is unclear if outcome assessors were blind, and the effect estimate was imprecise |
| Duration of surgery (min) Operative time | The mean duration of surgery in placebo group was 60 min | The mean duration of surgery in intervention group was 5.00 min higher (1.29 to 8.71 higher) |
MD 5.00 (1.29 to 8.71) |
50 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, it is unclear if outcome assessors were blind, and the effect estimate was imprecise |
| CI: Confidence interval;MD: Mean difference; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Allocation concealment not reported.