Summary of findings 7. Ascorbic acid compared to no treatment to reduce blood loss during myomectomy for fibroids.
| Ascorbic acid compared to placebo or no treatment to reduce blood loss during myomectomy for fibroids | ||||||
| Patient or population: Women with fibroids Settings: Tertiary hospital in Iran Intervention: Ascorbic acid Comparison: No treatment | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| No treatment | Ascorbic acid | |||||
| Blood loss (ml) Estimated blood loss during myomectomy | The mean blood loss in the control group was 932.9 ml | The mean blood loss in the intervention group was 411.46 ml lower (502.58 to 320.34 lower) |
MD ‐411.46 (‐502.58 to ‐320.34) |
102 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, and it is unclear how allocation concealment was done |
| Need for blood transfusion Participants who received blood transfusion | 180 per 1000 | 68 per 1000 (20 to 238) | OR 0.38 (0.11 to 1.32) | 104 (1 study) | ⊕⊝⊝⊝ very low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, it is unclear how allocation concealment was done, and the estimate was imprecise |
| Duration of surgery (min) Operative time | The mean duration of surgery in the control group was 68 min | The mean duration of surgery in the intervention group was 26.00 min lower (33.1 to 18.9 lower) |
MD ‐26.00 (‐33.10 to ‐18.90) |
102 (1 study) | ⊕⊕⊝⊝ low1 | We rated down the quality of evidence (by 2) because the data were derived from one small study, and it is unclear how allocation concealment was done |
| CI: Confidence interval; MD: Mean difference; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Allocation concealment not reported.