Comparison 1. Misoprostol versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Blood loss (ml)	2	89	Mean Difference (IV, Fixed, 95% CI)	‐97.88 [‐125.52, ‐70.24]
1.1 Abdominal myomectomy	1	25	Mean Difference (IV, Fixed, 95% CI)	‐149.0 [‐229.24, ‐68.76]
1.2 Laparoscopic myomectomy	1	64	Mean Difference (IV, Fixed, 95% CI)	‐91.0 [‐120.44, ‐61.56]
2 Need for blood transfusion	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3 Duration of surgery (min)	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 Abdominal myomectomy	1	25	Mean Difference (IV, Random, 95% CI)	‐9.5 [‐15.90, ‐3.10]
3.2 Laparoscopic myomectomy	1	64	Mean Difference (IV, Random, 95% CI)	9.0 [‐1.63, 19.63]
4 Postoperative haemoglobin (g/dl)	2	89	Mean Difference (IV, Fixed, 95% CI)	0.69 [0.37, 1.02]
5 Duration of hospital stay (days)	1	25	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.82, 0.82]
6 Postoperative haemoglobin drop (g/dl)	1	67	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐0.78, ‐0.42]
7 Postoperative complications	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 Postoperative fever	2	89	Odds Ratio (M‐H, Fixed, 95% CI)	0.94 [0.23, 3.88]