Date	Event	Description
5 July 2014	New search has been performed	Six additional trials have been included in the current update (Kalogiannidis 2011; Leone Maggiore 2011; Zhao 2011; Pourmatroud 2012; Vercellino 2012; Shokeir 2013). Five new interventions have been added to the review: ascorbic acid, dinoprostone, loop ligation of myoma pseudocapsule, temporary clipping of uterine artery and fibrin sealant patch (surgical patch coated with fibronogen and thrombin to stop bleeding of internal organs).
5 July 2014	New citation required and conclusions have changed	The conclusions of the review have changed.
18 July 2011	New citation required and conclusions have changed	Two additional trials have been included in this update. One of the new trials compared peri‐cervical tourniquet with no treatment (Ikechebelu 2010). With this new trial, there are now two trials on peri‐cervical tourniquet included in this review. The inclusion of the new trial to this review has changed the conclusions; unlike the previous versions of the review where we concluded that there is limited evidence that peri‐cervical tourniquet reduce blood loss during myomectomy, the conclusion in the current updated version is that there is no evidence that peri‐cervical tourniquet has an effect on blood loss. The other new trial compared the application of gelatin‐thrombin matrix to the uterine incision with normal saline (Raga 2009). There is evidence from this second trial that gelatin thrombin matrix reduced uterine bleeding.The previous versions of this review did not include any trial on gelatin thrombin matrix.
20 September 2010	Amended	Contact details updated.
13 February 2009	New citation required but conclusions have not changed	Two additional trials have been included in this update: one of the new trials compared intravenous oxytocin with a placebo (Wang 2007) and the other trial compared intravenous infusion of tranexamic acid with a placebo (Caglar 2008). In addition to the limited evidence from the original version of this review that misoprostol, vasopressin, bupivacaine plus epinephrine, tourniquet, and mesna may reduce bleeding during myomectomy, we found limited evidence in this updated version that tranexamic acid may also reduce bleeding. No major changes were made to the protocol.
14 November 2006	New citation required and conclusions have changed	Substantive amendment