Celik 2003.

Methods	Single centre study Described as randomised, but no details on how patients were allocated to trial interventions Both patients, care providers, and outcome assessors were blinded to treatment allocation Power calculation: performed No losses to follow up, and all patients were analysed in groups to which they were assigned Source of funding: not mentioned
Participants	Setting: university hospital, Elazig, Turkey Inclusion criteria: symptomatic uterine fibroids scheduled for myomectomy n = 25 Mean age: 31.7 years (SD 4.4) in the treatment arm and 32.2 years (SD 2.9) in the placebo group Ethnicity: not mentioned
Interventions	Treatment arm (n = 13): 400 uG misoprostol administered vaginally 1 hour before surgery Control arm (n = 12): placebo of identical shape and colour Sizes of fibroids: mean diameter of myomas 150.7 mm (SD 28.6) in the treatment arm and 154.2 mm (SD 24.7) in the control arm Type of operation: laparotomy
Outcomes	Perioperative blood loss, postoperative haemoglobin, operation time, blood transfusion, hospital stay, and postoperative morbidity Blood loss determined by aspiration equipment during the operation
Notes	Indication for myomectomy: symptomatic uterine fibroid Authors not contacted
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as randomised, but no details on how patients were allocated to trial interventions
Allocation concealment (selection bias)	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	Low risk	No incomplete outcome data
Selective reporting (reporting bias)	Unclear risk	We do not have access to the study protocol
Other bias	Low risk	No other sources of bias identified
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Both participants and personnel were blinded to treatment allocation
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome assessors were blinded to treatment allocation