Comparison 2. Behavior and/or Mood: Melatonin vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Behavioral and Mood Score at endpoint from baseline (NPI, 7 weeks, 2.5 mg MLT; ADAS non‐cognitive, 4 weeks, 3 mg MLT)	2	121	Mean Difference (IV, Random, 95% CI)	‐3.48 [‐4.89, ‐2.07]
2 Behavioral and Mood Score at endpoint from baseline (NPI, 7 weeks, 10 mg MLT)	1	97	Mean Difference (IV, Fixed, 95% CI)	0.63 [‐4.58, 5.84]
3 NPI‐Q Severity Score at final endpoint measure (6 weeks, 2.5 mg MLT)	1	94	Mean Difference (IV, Fixed, 95% CI)	‐1.60 [‐3.63, 0.43]
4 NPI‐Q Severity Score at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	‐0.70 [‐1.00, 1.60]
5 NPI‐Q severity Score at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐2.70 [‐7.70, 2.30]
6 Cohen‐Mansfield Agitation Inventory Score at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	‐1.0 [‐8.06, 6.06]
7 Cohen‐Mansfield Agitation Inventory Score at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐9.64, 9.64]
8 Cohen‐Mansfield Agitation Inventory Score at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐14.0 [‐29.89, 1.89]
9 Behavior and Mood score in Multi Observation Scale for Elderly Subjects at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	1.70 [‐0.85, 4.25]
10 Behavior and Mood score in Multi Observation Scale for Elderly Subjects at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	2.20 [‐0.82, 5.22]
11 Behavior and Mood score in Multi Observation Scale for Elderly Subjects at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐2.90 [‐7.80, 2.00]
12 Cornell Depression Rating Scale Score for Dementia at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐2.71, 2.11]
13 Cornell Depression Rating Scale Score for Dementia at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	‐1.70 [‐5.99, 2.59]
14 Cornell Depression Rating Scale Score for Dementia at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐5.0 [‐12.47, 2.47]
15 Mood Score in Philadelphia Geriatric Centre Rating Scale (positive) at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	‐1.0 [‐2.04, 0.04]
16 Mood score in Philadelphia Geriatric Centre Affect Rating Scale (positive) at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	‐1.60 [‐3.14, ‐0.06]
17 Mood score in Philadelphia Geriatric Centre Affect Rating Scale (positive) at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐2.57, 2.17]
18 Mood score in Philadelphia Geriatric Centre Affect Rating Scale (negative) at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	‐0.5 [‐1.65, 0.65]
19 Mood score in Philadelphia Geriatric Centre Affect Rating Scale (negative) at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	1.30 [‐0.05, 2.65]
20 Mood score in Philadelphia Geriatric Centre Affect Rating Scale (negative) at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐2.3 [‐4.96, 0.36]
21 Mood score in Philadelphia Geriatric Centre Morale Scale at final endpoint measure (6 weeks, 2.5 mg MLT)	1	86	Mean Difference (IV, Fixed, 95% CI)	1.10 [‐0.88, 3.08]
22 Mood score in Philadelphia Geriatric Centre Morale Scale at final endpoint measure (1 year, 2.5 mg MLT)	1	49	Mean Difference (IV, Fixed, 95% CI)	0.30 [‐2.79, 3.39]
23 Mood score in Philadelphia Geriatric Centre Morale Scale at final endpoint measure (2 years, 2.5 mg MLT)	1	19	Mean Difference (IV, Fixed, 95% CI)	‐1.70 [‐6.74, 3.34]