FIG 5.

Longitudinal adherence profiles observed in 8 subjects (S1 to S8) enrolled in the P3 study. Profiles are grouped into four types: consistent high adherence (A), high adherence with occasional missed doses (B), dramatically improved adherence after study initiation (C) and intermittent adherence (D). Images are arranged as hair samples would be analyzed most recent information (T1 visit) closest to the hair follicle on the left and baseline information (T0 visit) on the right. Inset values are intracellular metabolite concentrations (fmol/sample) measured in paired DBS samples. These values are color coded based on adherence categorization (for FTCtp, green indicates dosing within 7 days and red indicates no recent dosing; for TFVdp, green indicates >6 doses/week, yellow indicates 4 to 6 doses/week, and red indicates <4 doses/week).