TABLE 2.

Self-reported and objective adherence classifications for P3 study samples

Patient	% adherence in last moa	Started and stopped PrEPa	Sampling time point	DBS analysis				IR-MALDESI MSI
				FTCtp		TFVdp		Days above adherence threshold	Days below threshold: detectable response	Days below threshold: no response	Avg consecutive days below threshold
				Concn (fmol/sample)	Adherence classification	Concn (fmol/sample)	Adherence classification
S1	80	Yes	T0	528	Recent dosing	2,370	High	25	3	2	2.5
			T1	643	Recent dosing	2,820	High	30	0	0	0
S2	80	No	T0	275	Recent dosing	1,460	Medium	30	0	0	0
			T1	BLQ	No recent dosing	1,170	Medium	30	0	0	0
S3	70	Yes	T0	372	Recent dosing	1,620	Medium	30	0	0	0
			T1	417	Recent dosing	1,710	Medium	30	0	0	0
S4	80	No	T0	602	Recent dosing	1,690	Medium	30	0	0	0
			T1	355	Recent dosing	1,410	Medium	10	20	0	4
S5	60	Yes	T0	BLQ	No recent dosing	503	Low	0	14	16	30
			T1	151	Recent dosing	456	Low	3	9	18	27
S6	40	No answer	T0	BLQ	No recent dosing	378	Low	1	17	12	14.5
			T1	329	Recent dosing	951	Low	30	0	0	0
S7	70	No	T0	BLQ	No recent dosing	488	Low	2	22	6	14
			T1	685	Recent dosing	1,490	Medium	21	4	5	9
S8	100	Yes	T0	BLQ	No recent dosing	BLQ	Low	0	8	22	30
			T1	BLQ	No recent dosing	176	Low	0	9	21	30

^aSelf-reported in adherence presurvey.