TABLE.

Polygenic Risk Score Results Stratified by Brain Cell Type

Data set	Tissue	Cell type	R2	P	Coefficient	No. of SNPs
Training data set 7,218 PD 9,424 controls	Brain	Microglia	0.058	6.9e-163	0.48	1,032
		Neurons	0.055	2.9e-152	0.46	886
		Astrocytes	0.048	1.3e-134	0.43	847
		Oligodendrocytes	0.050	9.0e-141	0.44	842
	Immune	Monocytes	0.084	1.4e-227	0.58	1,915
		B cells	0.061	4.8e-168	0.49	1,049
		CD4+ T cells	0.056	2.4e-156	0.47	890
		CD8+ T cells	0.055	9.0e-153	0.46	888
Test data set 5,429 PD 5,814 controls	Brain	Microglia	0.029	6.1e-56	0.31	1,032
		Neurons	0.024	3.6e-46	0.28	886
		Oligodendrocytes	0.020	2.6e-39	0.26	842
		Astrocytes	0.019	7.1e-37	0.25	847
	Immune	B cells	0.029	2.4e-54	0.31	1,049
		CD4+ T cells	0.029	3.8e-54	0.31	890
		CD8+ T cells	0.026	6.4e-49	0.29	888
		Monocytes	0.026	1.7e-48	0.29	1,915

Association results of polygenic risk scores modeled on summary statistics from an independent genomewide association study and stratified to include variants within open chromatin regions for various cell types. Scores were generated using the PRSice software tool with a cutoff of p < 0.05 in the reference data. Within each dataset and tissue, results are ordered with the best performing model first.

SNPs = single-nucleotide polymorphisms.