Table 1.

MR analysis between RLS and PD

					Inverse variance weighted				MR Egger				Weighted median
Exposure	Outcome	F	R 2	MR-PRESSO	b	SE	P	Q test p	b	SE	P	Q test p	b	SE	P
RLS	PD	217.558	0.035	0.832	−0.003	0.031	0.916	0.780	−0.019	0.064	0.767	0.729	−0.020	0.043	0.632
PD	RLS	191.791	0.0315	0.662	−0.012	0.023	0.592	0.300	−0.002	0.050	0.958	0.269	−0.011	0.036	0.749

RLS, restless legs syndrome; PD, Parkinson’s disease; F, “strength” of the genetic instrumental variable; R², proportion of variance in exposure variable explained by SNPs; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier; MR, Mendelian randomization; b, beta; SE, standard error; Q, Cochran’s Q test.