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. 2022 Apr 5;9:874254. doi: 10.3389/fnut.2022.874254

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Copyright © 2022 Dasdelen, Er, Kaplan, Celik, Beker, Orhan, Tuzcu, Sahin, Mamedova, Sylla, Komorowski, Ojalvo, Sahin and Kilic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of L-theanine and Mg-L-theanine compounds on brain electrical activity. Representative ECoG recordings for each group (A) and analyses of spike frequency (B) and amplitude (C) on ECoG. Values are represented as mean ± SEM for each group, n = 6. Symbols indicate significance by Fisher’s LSD as *p < 0.05 between Control and C/Control, ^#p < 0.05 between C/Control and C/Mg-T1 groups. Frequency-power graphs of L-theanine (D), Mg-T1 (E), and Mg-T2 (F) at 50th and 100th minutes for 0–30 Hz range show restoration of slow brain waves after caffeine-induced decline which is then separately graphed for comparison of delta power between groups (G). Average of the 1200 FFTs (10 min following 50th and 100th minutes) were calculated for each animal. ^#p < 0.05 compared to C/Control group. All values are represented as mean ± SEM.