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(Left) i.v. and p.o. PK curves in mice over 24 h on administration of 22 at 2 mg/kg and 20 mg/kg, respectively. (Right) PK of 22 on escalation of the p.o. dose. Dashed lines indicate the concentrations from in vitro data against M. tuberculosis H37Rv constitutively expressing DsRed in macrophages and against the replicating Erdman strain of M. tuberculosis.
