FIG 5.

BALB/c mice were infected with M. tuberculosis Erdman Lux via a low-dose aerosol exposure. Treatment was started 7 days postaerosol and continued for 12 consecutive days. Drugs were administered once daily by oral gavage at the dose indicated. Plots represent log₁₀ CFU determinations in lungs (A) and spleens (B) of individual BALB/c mice with the group means shown (solid horizontal line). The lower limit of detection in spleens was 1.7 log (indicated with a dashed line). P values determined by a one-way analysis of variance with a Dunnett’s multiple-comparison test are listed.