TABLE 5.

PK properties of compound 22 in mouse^e

Route of administration	Dose (mg/kg)	Cmax (μg/mL)	Tmax (h)	t1/2 (h)	CLba (mL/min/kg)	CLub (mL/min/kg)	Vss (liters/kg)	AUC0–∞c (h· μg/mL)	Fd (%)
i.v.	2			3.7	14.3	210	5.1	2.37
p.o.	20	9.5	1.0					24.6	104
p.o.	100	47	2.8					343
p.o.	300	133	1.0					1271
p.o.	500	117	0.83					1435

^aBlood clearance.

^bUnbound clearance based on PPB = 93.2%.

^cArea under the curve.

^dOral bioavailibility.

^eT_max, time to maximum concentration of drug in serum; t_1/2, half-life. V_ss, volume at steady state.