TABLE 1.
Bacterial C-terminal processing proteases in the literature
| Species and CTPsa | Notable null phenotypeb | Known or proposed substrates(s) | Selected references |
|---|---|---|---|
| Acinetobacter baumannii | |||
| Ctp WP_000776302.1 | Reduced virulence | None | (23, 24) |
| Bacillus subtilis | |||
| CtpA WP_003231186.1 | DNA damage sensitivity | YneA | (41, 42) |
| CtpB WP_003228041.1 | Sporulation defect | SpoIVFA | (39, 40, 74–76) |
| Bartonella bacilliformis | |||
| CtpA WP_005766244.1 | Not tested | None | (77) |
| Bordetella Bronchiseptica | |||
| CtpA WP_033446625.1 | Defective FHA processing | FhaBc | (27) |
| Borrelia burgdorferi | |||
| CtpA WP_002656708.1 | Reduced growth rate | P13c, BB0323c, OspCc | (29, 30) |
| Brucella suis | |||
| CtpA WP_004690508.1 | Reduced virulence | None | (20) |
| Burkholderia mallei | |||
| CtpA WP_004198008.1 | Reduced virulence | None | (21) |
| Burkholderia pseudomallei | |||
| Prc WP_004534131.1 | Meropenem sensitivity | None | (22) |
| Chlamydia trachomatis | |||
| CT441 WP_010725198.1 | Not tested | NF-κB p65 subunit (host protein)c,d | (31, 32, 35) |
| Escherichia coli K-12 | |||
| Prc WP_032199908.1 | Thermosensitive at low osmolarity | FtsI, MepM, MepS, MltG, MltBc, DigHc | (6, 9, 50, 62–64, 67, 78) |
| Legionella pneumophila | |||
| Tsp WP_010946247.1 | Thermal stress sensitivity | None | (15, 79) |
| Paenibacillus lautus | |||
| CtpA WP_015737691.1 | Not tested | None | (80) |
| Pseudomonas aeruginosa | |||
| CtpA WP_003096067.1 | Reduced virulence | MepM, PA1048, PA1198, PA1199, PA4404 | (3, 68, 69) |
| Prc WP_003091593.1 | Suppresses mucoid phenotype | MucA22c, FoxRc, FiuRc | (47, 55, 59, 81) |
| Pseudomonas putida | |||
| Prc WP_164721827.1 | Altered cell surface signaling | IutYc, PP_0161 (FoxR)c, PP_0351 (FiuR)c | (47, 49) |
| Staphylococcus aureus | |||
| CtpA WP_000342125.1 | Reduced virulence | SosAc | (43, 82) |
| Synechocystis sp. PCC 6803 | |||
| CtpA WP_010873417.1 | Photosynthesis defect | D1 | (12, 14) |
| Vibrio cholerae | |||
| Tsp WP_000650135.1 | Altered TcpP cleavage | TcpPc | (46) |
| Xanthomonas campestris | |||
| Prc WP_014509001.1 | Osmostress sensitivity | VgrS | (44, 45) |
a
Listed alphabetically by genus. The name of each protease as first reported in the literature is followed by a National Center for Biotechnology Information RefSeq non-redundant protein identification number.
b
In some cases, multiple phenotypes have been reported for protease null strains (see references) but only one of the notable phenotypes is listed.
c
Not confirmed to be directly cleaved/degraded by the purified protease in vitro.