TABLE 3.

Plasma pharmacokinetic parameters of sutezolid

Parameter	Cohort 1 (300 mg)				Cohort 2 (600 mg)				Cohort 3 (1,200 mg)				Cohort 4 (1,800 mg)
	n	Mean	SD	CV%	n	Mean	SD	CV%	n	Mean	SD	CV%	n	Mean	SD	CV%
Tmax (h)	6	2.18	0.94	43.15	6	2.25	1.54	68.49	6	1.75	1.13	64.52	6	2.50	1.52	60.66
Cmax (ng/mL)	6	408	109	26.81	6	782	211	27.06	6	1,440	571	39.62	6	1,550	633	40.85
AUClast (h · ng/mL)	6	1,810	490	27.11	6	3,690	694	18.80	6	7,720	3,060	39.63	6	11,400	5,350	47.08
AUCinf (h · ng/mL)	6	1,880	482	25.56	6	3,810	686	18.01	6	8,020	3,160	39.45	5	14,100	5,880	41.66
AUCextrap (%)	6	4.43	1.90	42.90	6	3.14	1.12	35.52	6	3.80	1.64	43.17	5	7.23	6.31	87.33
λz (h−1)	6	0.175	0.0308	17.67	6	0.134	0.0585	43.59	6	0.0851	0.0194	22.83	5	0.0774	0.0442	57.13
t1/2 (h)	6	4.08	0.773	18.93	6	5.74	1.61	28.00	6	8.48	1.79	21.07	5	11.7	6.80	58.05
Tlast (h)	6	17.3	4.13	23.83	6	23.7	4.46	18.83	6	40.0	9.03	22.58	6	42.0	9.30	22.13
Clast (ng/mL)	6	13.2	1.31	9.92	6	14.0	2.45	17.53	6	23.8	11.6	48.84	6	51.2	42.0	81.99
CL/F (L/h)	6	167	38.2	22.83	6	161	27.1	16.78	6	167	54.8	32.89	5	145	55.4	38.25
Vz/F (L)	6	990	335	33.82	6	1,360	436	32.09	6	2,060	898	43.60	5	2,040	382	18.71