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(A–D) Pharmacodynamics of meropenem at 5, 10, and 30 mg/kg q8h i.v. as assessed using the bacterial burden in the CSF of rabbits infected with P. aeruginosa ATCC 27853. Treatment was initiated 6 h postinoculation at time = 0. The solid black lines in each panel are locally weighted scatterplot smoothing (LOWESS) regression lines fitted to the pooled data from each cohort of rabbits.
