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(A–D) Pharmacodynamics of tobramycin at 0.67, 2, and 3.33 mg/kg q8h i.v. as assessed using the bacterial burden in the CSF of rabbits infected with P. aeruginosa ATCC 27853. Treatment was initiated 6 h postinoculation at time = 0. The solid black lines in each panel are LOWESS regression lines fitted to the pooled data from each cohort of rabbits. There was no obvious dose exposure response relationship.
