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Pharmacodynamics of meropenem and tobramycin in a hollow fiber infection model with P. aeruginosa ATCC 27853 as the challenge strain. Artificial CSF (aCSF) medium was used as the medium. (A and B) Neonatal CSF concentration time profiles of meropenem (A) and tobramycin (B) were used, and the AUC:MIC values quantify drug exposure in the CSF. An exposure response relationship is evident for meropenem. In contrast, bacterial killing induced by tobramycin is minimal.
