TABLE 1.
Population PK-PD parameters for meropenema
| Parameterb (units) | Mean | Median | SD |
|---|---|---|---|
| Clearance (L/h) | 3.409 | 3.388 | 0.919 |
| Vol (L) | 1.212 | 1.045 | 0.811 |
| K12 (h−1) | 3.059 | 1.694 | 3.716 |
| K21 (h−1) | 3.347 | 3.113 | 4.469 |
| K13 (h−1) | 0.076 | 0.082 | 0.026 |
| K31 (h−1) | 0.728 | 0.738 | 0.283 |
| Vol CSF (L) | 2.577 | 2.123 | 1.565 |
| Kgmax (log10 CFU/mL/h) | 0.387 | 0.284 | 0.307 |
| popmax (CFU/mL) | 3,352,281 | 144,355 | 4,406,617 |
| kkmax (log10 CFU/mL/h) | 0.859 | 0.860 | 0.117 |
| Hk | 8.866 | 4.517 | 6.678 |
| C50k (mg/L) | 0.075 | 0.079 | 0.021 |
| Initial condition (CFU/mL) | 721 | 739 | 271 |
a
The population PK-PD parameters for meropenem are from the rabbit model.
b
Parameters are defined in Materials and Methods.