Table 3.
Relationship between body composition parameters, sarcopenia classification results, and the clinical outcome parameters length of stay, invasive mechanical ventilation (IVM), and time to death.
| Spearman's correlation | Logistic regression | Cox regression | ||||
|---|---|---|---|---|---|---|
| Length of stay | IMV | Time to death | ||||
| r | Adj. OR [95% CI] | P-value | Adj. HR [95% CI] | P-value | ||
| SMA L3 [cm2] | − 0.211 | 0.996 [0.961–1.033] | 0.837 | 1.002 [0.986–1.018] | 0.841 | |
| SMI | − 0.265 | 1.025 [0.913–1.150] | 0.677 | 1.008 [0.958–1.060] | 0.762 | |
| SMA T12 [cm2] | − 0.178 | 1.019 [0.918–1.130] | 0.724 | 0.985 [0.941–1.031] | 0.513 | |
| MRA L3 [HU] | − 0.186 | 1.053 [0.955–1.161] | 0.299 | 1.007 [0.959–1.057] | 0.792 | |
| MRA T12 [HU] | − 0.023 | 0.998 [0.923–1.078] | 0.956 | 0.996 [0.963–1.030] | 0.807 | |
| SUBCUTANEOUS FAT L3 [cm2] | − 0.236 | 0.983 [0.963–1.003] | 0.093 | 1.001 [0.995–1.007] | 0.683 | |
| SUBCUTANEOUS FAT T12 [cm2] | − 0.227 | 0.981 [0.954–1.009] | 0.190 | 0.998 [0.989–1.007] | 0.653 | |
| VISCERAL FAT AREA L3 [cm2] | 0.027 | 1.005 [0.991–1.020] | 0.500 | 0.997 [0.990–1.005] | 0.495 | |
| VISCERAL FAT MASS [kg] | − 0.356 | 0.342 [0.070–1.676] | 0.186 | 1.225 [0.752–1.996] | 0.415 | |
| WHOLE BODY FAT MASS [kg] | − 0.349 | 0.907 [0.781–1.053] | 0.198 | 1.008 [0.960–1.059] | 0.736 | |
| FMR | − 0.025 | 0.213 [0.035–1.276] | 0.090 | 1.492 [0.567–3.931] | 0.418 | |
| Linear regression | OR [95% CI] | P-value | HR [95% CI] | P-value | ||
|---|---|---|---|---|---|---|
| Length of stay | ||||||
| Mean diff. [95% CI] | P-value | |||||
| Sarcopenic patients according to Prado et al. | − 0.155 [− 0.477 to 0.167] | 0.333 | 4.200 [0.645 to 27.362] | 0.133 | 0.535 [0.122 to 2.345] | 0.407 |
| Sarcopenic patients according to Martin et al. | − 0.098 [− 0.423 to 0.227] | 0.543 | 1.667 [0.243 to 11.448] | 0.603 | 0.435 [0.100 to 1.900] | 0.268 |
| Patients < 5th SMI percentile of van der Werf et al. | − 0.131 [− 0.413 to 0.150] | 0.348 | 1.714 [0.266 to 11.060] | 0.571 | 0.870 [0.343 to 2.209] | 0.770 |
| Patients < 5th MRA percentile of van der Werf et al. | − 0.180 [− 0.500 to 0.140] | 0.259 | –* | –* | 1.170 [0.414 to 3.305] | 0.768 |
Regression analyses for the metric independent variables were adjusted for sex, age, and body mass index (BMI). Detailed results for all adjusting variables are listed in Supplement Table 1.
IMV = invasive mechanical ventilation, SMA = skeletal muscle area, L3 = at the level of the third lumbar vertebra, SMI = skeletal muscle index, T12 = at the level of the twelfth thoracic vertebra, MRA = muscle radiodensity attenuation, HU = Hounsfield units, FMR = fat to muscle ratio, adj. OR = adjusted odds ratio, CI = confidence interval, Adj. mean difference = adjusted mean difference, Adj. HR = adjusted hazard ratio.
*Model not applicable due to low event numbers.