Table 2.

Three-way MANOVA for pain ratings, PCS scores, and PROMIS measures.

Measures		Λ	F	df	p
Average pain intensity PCS scores	Sex	0.994	22.62	(2, 7506)	< 0.000
	Time	1.000	0.07	(2, 7506)	0.932
	Month	0.998	0.95	(12, 15,012)	0.455
	Time × month	0.997	2.01	(12, 15,012)	0.020
	Sex × time	0.999	2.34	(2, 7506)	0.096
	Sex × month	0.999	0.70	(12, 15,012)	0.752
	Sex × time × month	0.999	0.79	(12, 15,012)	0.660
Pain interference Physical function Fatigue Sleep impairment	Sex	0.984	30.26	(4, 7504)	< 0.001
	Time	0.998	4.41	(4, 7504)	0.001
	Month	0.996	1.24	(24, 26,180)	0.196
	Time × month	0.996	1.19	(24, 26,180)	0.240
	Sex × time	0.999	2.74	(4, 7504)	0.027
	Sex × month	0.997	1.01	(24, 26,180)	0.443
	Sex × time × month	0.998	0.67	(24, 26,180)	0.887
Depression Anxiety Anger Social isolation Emotional support Satisfaction with social roles and activities	Sex	0.983	22.10	(6, 7502)	< 0.001
	Time	0.996	5.12	(6, 7502)	< 0.001
	Month	0.995	1.04	(36, 32,946)	0.396
	Time × month	0.997	0.69	(36, 32,946)	0.917
	Sex × time	0.999	0.71	(6, 7502)	0.643
	Sex × month	0.994	1.25	(36, 32,946)	0.917
	Sex × time × month	0.997	0.71	(36, 32,946)	0.906

Bold font indicates significance at p < 0.05.